Propofol is used in the operating room to induce anesthesia. To maintain anesthesia, a continuous infusion of the agent via a separate syringe pump is the standard procedure for total intravenous anesthesia. However, this is not entirely sustainable: propofol produces about 45 percent of the drug waste in the operating room, and a quarter of the agent remains unused. Researchers at the University Hospital Bonn (UKB) and the University of Bonn have now shown that an alternative method reduces the amount of waste. Instead of a separate syringe for the induction and maintenance of anesthesia, the researchers were able to show that the use of a single syringe pump for the induction and maintenance of anesthesia is more sustainable: propofol waste could be reduced by between 30 and 50 percent. The study has now been published in the British Journal of Anaesthesia.

The University of Bonn has further advanced in the latest Times Higher Education (THE) World University Ranking 2025, now ranking 89th worldwide—up two slots since last year. In Germany it improved as well, climbing one slot to fifth place, in the company of the country’s other leading institutions like Technical University of Munich, the Ludwig Maximilian University of Munich, the University of Heidelberg and Humboldt University of Berlin.

We often only realize how important our sense of smell is when it is no longer there: food hardly tastes good, or we no longer react to dangers such as the smell of smoke. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the University of Aachen have investigated the neuronal mechanisms of human odor perception for the first time. Individual nerve cells in the brain recognize odors and react specifically to the smell, the image and the written word of an object, for example a banana. The results of this study close a long-standing knowledge gap between animal and human odor research and have now been published in the renowned journal "Nature".

The genetic confirmation of a suspected diagnosis of "hereditary colorectal cancer" is of great importance for the medical care of affected families. However, many of the variants identified in the known genes cannot yet be reliably classified in terms of their causal role in tumor formation. Under the leadership of the University Hospital Bonn (UKB) and the University of Bonn, an international team of researchers has reassessed the medical relevance of a significant number of unclear variants and thus significantly reduced their number. The results of the study have now been published in the renowned journal "American Journal of Human Genetics".

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers. As methods for studying these processes in living cells have so far been inadequate, the sequence of oligomerization, pore formation and membrane incorporation has remained unclear. An international research team led by the University Hospital Bonn (UKB) and the University of Bonn has succeeded in answering this question with the help of antibody fragments, so-called nanobodies, which they have identified. They hope that this will lead to potential therapeutic applications. Their results have now been published in the journal "Nature Communications".

Despite its importance for mathematics, the neuronal basis of the number zero in the human brain was previously unknown. Researchers from the University Hospital Bonn (UKB), the University of Bonn and the University of Tübingen have now discovered that individual nerve cells in the medial temporal lobe recognize zero as a numerical value and not as a separate category "nothing". The results have now been published in the journal "Current Biology".

An unprecedented program is to be rolled out to deal with future pandemics: Researchers from the Universities of Melbourne and Bonn and University Hospital of Bonn are teaming up with a billionaire backer to develop new therapeutics and strengthen natural immune response. The Cumming Global Centre and the University of Bonn have today announced the creation of the Bonn-Cumming Host-Directed Pandemic Therapeutics Research Program. Initial program funding of €6 million may potentially be increased to up to €40 million. Philanthropic billionaire Geoff Cumming is putting up a large part of this funding.

Researchers at the University of Bonn and the University of Cambridge have identified an important control circuit involved in the eating process. The study has revealed that fly larvae have special sensors, or receptors, in their esophagus that are triggered as soon as the animal swallows something. If the larva has swallowed food, they tell the brain to release serotonin. This messenger substance – which is often also referred to as the feel-good hormone – ensures that the larva continues to eat. The researchers assume that humans also have a very similar control circuit. The results were recently published in the journal “Current Biology.”