To make your research in and with 3R methods more widely known and highly visible to the scientific community, you can now apply for the new "Paper of the Quarter".

Brown fat cells convert energy into heat – a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area "Life & Health" at the University of Bonn have now identified the protein EPAC1 as a new pharmacological target to increase brown fat mass and activity. The long-term aim is to find medicines that support weight loss. The results of the study have now been published in the renowned journal "Nature Cell Biology".

Some bacterial membrane transporters work almost like freight elevators to transport substances through the cell membrane into the interior of the cell. The transporter itself spans the bacterial membrane. Like a forklift, a soluble protein outside the bacterium transports the substance to the "elevator" and unloads its cargo there. The freight elevator transports it to the inside of the cell, in other words to another floor. Researchers at the University Hospital Bonn (UKB) and the University of Bonn, in collaboration with a team from the University of York, have now studied the interaction between the transporter and its soluble substrate binding protein. Interestingly, they adapt precisely to each other during the transportation process. As this happens very quickly, the researchers virtually "blocked" the elevator by specifically inserting anchors, so-called disulphide bridges. This enabled them to prove that only the loaded "forklift" fits the "elevator" if it is on the right floor. This makes transportation really effective. The study has now been published in the journal "Nature Communications".

The 2023 Ideas Competition organized by the Transfer Center enaCom once again impressively demonstrated the innovative potential of the University of Bonn. Eight candidates made it through to the final on December 6 and pitched their ideas to the jury and audience at the Digitalhub at Bonn's central station. Three of them convinced the distinguished jury: "UniTalks" by Daria Kononenko and "Inspired by Learning" by Fabian Mantsch and Lars Pfleider each won 1,000 euros donated by the Universitätsstiftung Bonn and Comma Soft AG. The idea "PlateProfit" by Leon Schmidt won the Digital Startup Prize from DIGITALHUB.DE.
 
 

A delegation from the University of Bonn has visited Australia with three main aims in mind: to cultivate partnerships, strengthen exchange programs and explore options for joint research. Existing cooperation arrangements were stepped up on the trip and new ones agreed for the future.
 
 

For successful fertilization, sperm should move forward rapidly and be shaped correctly. The unique structure of the sperm cells forms during spermiogenesis. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that fertility problems in both mice and humans can be caused by loss of so-called cylicines. This causes defects in head and tail structure of sperm. The results of the study have now been published in the scientific journal "eLife".

Dermatologist Prof. Jörg Wenzel of Bonn University Hospital and University of Bonn has collaborated with Incyte, a U.S.-based global biopharmaceutical company, to develop a strategy for treating patients with severe pruritus (prurigo nodularis) with ruxolitinib cream. The University of Bonn and Incyte have now entered into an agreement whereby Incyte has acquired the rights to a related joint patent application from Bonn.

Innovations in AI-assisted social sciences, sustainable agriculture and medicine are being funded in the third round of prototyping grants by the Transfer Center enaCom at the University of Bonn. Whether an AI solution for better understanding of scientific communities, a robot that treats weeds differently depending on the species, or a preventive nasal spray - scientists from the University of Bonn and the University Hospital Bonn are developing innovative prototypes for practical challenges of our time. With the prototyping grants, their research findings are prepared for a planned commercialization. The grants with a funding amount of up to €50,000 are regularly awarded by the Transfer Center.