The genetic confirmation of a suspected diagnosis of "hereditary colorectal cancer" is of great importance for the medical care of affected families. However, many of the variants identified in the known genes cannot yet be reliably classified in terms of their causal role in tumor formation. Under the leadership of the University Hospital Bonn (UKB) and the University of Bonn, an international team of researchers has reassessed the medical relevance of a significant number of unclear variants and thus significantly reduced their number. The results of the study have now been published in the renowned journal "American Journal of Human Genetics".

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers. As methods for studying these processes in living cells have so far been inadequate, the sequence of oligomerization, pore formation and membrane incorporation has remained unclear. An international research team led by the University Hospital Bonn (UKB) and the University of Bonn has succeeded in answering this question with the help of antibody fragments, so-called nanobodies, which they have identified. They hope that this will lead to potential therapeutic applications. Their results have now been published in the journal "Nature Communications".

Despite its importance for mathematics, the neuronal basis of the number zero in the human brain was previously unknown. Researchers from the University Hospital Bonn (UKB), the University of Bonn and the University of Tübingen have now discovered that individual nerve cells in the medial temporal lobe recognize zero as a numerical value and not as a separate category "nothing". The results have now been published in the journal "Current Biology".

An unprecedented program is to be rolled out to deal with future pandemics: Researchers from the Universities of Melbourne and Bonn and University Hospital of Bonn are teaming up with a billionaire backer to develop new therapeutics and strengthen natural immune response. The Cumming Global Centre and the University of Bonn have today announced the creation of the Bonn-Cumming Host-Directed Pandemic Therapeutics Research Program. Initial program funding of €6 million may potentially be increased to up to €40 million. Philanthropic billionaire Geoff Cumming is putting up a large part of this funding.

Researchers at the University of Bonn and the University of Cambridge have identified an important control circuit involved in the eating process. The study has revealed that fly larvae have special sensors, or receptors, in their esophagus that are triggered as soon as the animal swallows something. If the larva has swallowed food, they tell the brain to release serotonin. This messenger substance – which is often also referred to as the feel-good hormone – ensures that the larva continues to eat. The researchers assume that humans also have a very similar control circuit. The results were recently published in the journal “Current Biology.”

Across all species, critical skills are passed on from parents to offspring through communication. Researchers at the University Hospital Bonn (UKB) and the Researchers at the University of Bonn showed that effective communication relies on how both the sender and receiver represent information. Their study reveals how this process underlies training efficacy and task performance. Their results have been published in the journal "Nature Communications".

Innovations such as a chatbot that talks to patients while recording medical data or a new test procedure for genetic defects in infertile men are being funded by the Transfer Center enaCom in the 5th round of prototyping grants. Two teams of scientists from the University of Bonn and the University Hospital Bonn (UKB) are developing innovative prototypes for practical challenges of our time. The findings from the research are prepared for planned commercialization with the prototyping grants. The grants with a funding amount of up to €50,000 are regularly announced by the Transfer Center. Applications for a final funding round in 2024 can still be submitted until 15.09.2024.

From infancy and usually for life, some families suffer from broken hair due to a congenital form of hair loss called monilethrix. Researchers at the University Hospital Bonn and the University of Bonn have now identified causative mutations in another keratin gene, KRT31. They hope that this will improve the diagnosis of this rare disease. Their results have now been published in the renowned "British Journal of Dermatology".