News — Medical Faculty

Deciphering the sequence of neuronal firing¹

How does the brain retain a sequence of events in memory? Researchers from the University Hospital Bonn (UKB), the University of Bonn, the University Hospital Tübingen and the University of Tübingen investigated this question. Using a unique measurement technique with implanted electrodes in the human brain, they were able to test a widely accepted theory of memory processes for the first time. The response pattern of the nerve cells did not align with the theory, but could be explained by a new model. The results have now been published in the journal "Nature Neuroscience".

Starting points for the control of protein synthesis²

The research field of "cellular IRESes" lay dormant for decades, as there was no uniform standard of reliable methods for the clear characterization of these starting points for the ribosome-mediated control of gene expression. Researchers at the University Hospital Bonn (UKB) and the University of Bonn, in collaboration with Stanford University in California (USA), have now developed a toolbox as a new gold standard for this field. They hope to discover strong IRES elements that are directly relevant for synthetic biology and for application in emerging mRNA therapeutics. The results of their work have been published in The EMBO Journal.

Seven Subjects among the Top 100 Worldwide³

Higher education analyst Quacquarelli Symonds (QS) has published its international subject rankings for the year, in which 1,747 universities from around the world, including the University of Bonn, are compared based on various indicator criteria.

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Creating Personalized Cancer Treatments Using “Mini-Tumors” and a Digital Twin⁴

Funded by the Federal Ministry of Education and Research (BMBF), a collaborative project involving the University of Bonn, the company ESQlabs and the University Hospital Bonn is seeking to refine the therapy recommendations given to colon cancer patients. To this end, “ISPOT-K” is merging organoids taken from patients with the power of digital twin technology.

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Potential target for MS therapy discovered⁵

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by the immune system. B cells, which are a type of white blood cell, play a role in the development of MS and are thus a target for therapies. Researchers at the University Hospital Bonn (UKB), the University of Bonn and the FAU Erlangen-Nuremberg identified the membrane protein MLC1 as a potential target antigen in MS. To do this, the team used a novel combination of modern techniques. The results of the work have now been published in the renowned journal “Neurology Neuroimmunology & Neuroinflammation”.

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The secret behind sharp vision⁶

Even when we think we are holding our gaze perfectly still, our eyes make tiny, involuntary movements. While these "fixational eye movements" might seem like they would blur our vision, new research reveals they actually help us see fine details more clearly. The results of the study have now been published in "PNAS".

© Grün, Bauer, Rüber, Schultz: Deep Learning Based Tractography With TractSeg in Patients With Hemispherotomy: Evaluation and Refinement, NeuroImage: Clinical. https://doi.org/10.1016/j.nicl.2025.103738

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AI Enhances Brain Imaging⁷

How can nerve pathways in the brain be visualized to improve the planning of complex surgeries? A research team from the Lamarr Institute and the University of Bonn, in collaboration with the Translational Neuroimaging Group at the Departments of Neuroradiology and Epileptology at the University Hospital Bonn (UKB), has investigated an AI-powered method that makes these reconstructions more precise. The study, recently published in NeuroImage: Clinical, could ultimately help make neurosurgical procedures safer.

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Saving energy is "in", even neurons are joining in⁸

Nerve cells have amazing strategies to save energy and still perform the most important of their tasks. Researchers from the University Hospital Bonn (UKB) and the University of Bonn as well as the University Medical Center Göttingen found that the neuronal energy conservation program determines the location and number of messenger RNA (mRNA) and proteins, and differs depending on the length, longevity and other properties of the respective molecule. The work has now been published in the journal "Nature Communications".

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