The identification of genes involved in diseases is one of the major challenges of biomedical research. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have developed a method that makes their identification much easier and faster: they light up genome sequences in the cell nucleus. In contrast to complex screenings using established methods, the NIS-Seq method can be used to investigate the genetic determinants of almost any biological process in human cells. The study has now been published in Nature Biotechnology.

A deficiency in blood plasma coagulation factor XIII leads to a disruption in the cross-linking of fibrin, the "glue" in blood coagulation. The enzyme therefore plays an essential role in blood clotting. Researchers at the University Hospital Bonn (UKB) and the University of Bonn, together with Thermo Fisher Scientific in the Netherlands, deciphered the previously unknown structure of the Factor XIII complex using cryo-electron microscopy (cryo-EM), even at the atomic level. This enabled them to visualize the effects of disease-causing, clinically relevant factor XIII mutations in the structure of the coagulation complex. Their results have now been published in the print edition of the journal “Blood”.

Not one but two researchers at the University of Bonn and the University Hospital Bonn are to receive much-sought-after Consolidator Grants. Awarded by the European Research Council (ERC), they provide millions of euros in funding for outstanding research projects. Professor Philipp Vollmuth is developing an AI foundation model that is expected to set new benchmarks for the use of AI in radiology, while Privatdozent Dr. med. Michael Sommerauer—who recently swapped the University of Cologne for Bonn—is researching the early detection of Parkinson’s disease.

In the Funding Atlas 2024, recently published by the German Research Foundation (DFG), the University of Bonn has improved its standing significantly, surging from 15th out of all universities in 2021 to now stand 6th. The DFG’s Funding Atlas provides a clear yet detailed record of the funding provided by public-sector donors to Germany’s higher-education and research institutions between 2020 and 2022.

The University of Bonn has once again demonstrated its excellence as a research institution in the latest Global Ranking of Academic Subjects 2024—part of the high-profile Shanghai Ranking. Mathematics and Economics held on to their respective first-place rankings in Germany, enjoyed for several years now. Agricultural Sciences now ranks third nationally.

Immune cells are capable of detecting infections just like a sniffer dog, using special sensors known as Toll-like receptors, or TLRs for short. But what signals activate TLRs, and what is the relationship between the scale and nature of this activation and the substance being detected? In a recent study, researchers from the University of Bonn and the University Hospital Bonn (UKB) used an innovative method to answer these questions. The approach that they took might help to speed up the search for drugs to combat infectious diseases, cancer, diabetes or dementia. Their findings have been published in the journal “Nature Communications.”

Whether lying on their back, all-fours position, sitting upright or squatting - women adopt different birthing positions during childbirth. What has not yet been researched is how the respective final birthing position affects the satisfaction of the woman giving birth. Researchers from the University Hospital Bonn (UKB), the University of Bonn and the University of Cologne have now investigated precisely this. In particular, they also took into account whether the choice of birthing position was voluntary. The results showed that it was precisely when this was chosen voluntarily that women were more satisfied. Around three quarters of those surveyed were lying during the birth and were particularly dissatisfied if they felt that they had not made this choice themselves. However, if the expectant mothers had chosen the supine or lateral supine position themselves, the position actually tended to make them more satisfied. The study has now been published in the journal "Archives of Gynecology".

Our ability to see starts with the light-sensitive photoreceptor cells in our eyes. A specific region of the retina, termed fovea, is responsible for sharp vision. Here, the color-sensitive cone photoreceptors allow us to detect even the smallest details. The density of these cells varies from person to person. Additionally, when we fixate on an object, our eyes make subtle, continuous movements, which also differ between individuals. Researchers from the University Hospital Bonn (UKB) and the University of Bonn have now investigated how sharp vision is linked to these tiny eye movements and the mosaic of cones. Using high-resolution imaging and micro-psychophysics, they demonstrated that eye movements are finely tuned to provide optimal sampling by the cones. The results of the study have now been published in the journal "eLife".