Nerve cells in the brain receive thousands of synaptic signals via their "antenna", the so-called dendritic branch. Permanent changes in synaptic strength correlate with changes in the size of dendritic spines. However, it was previously unclear how the neurons implement these changes in strength across several synapses that are close to each other and active at the same time. Researchers from the University Hospital Bonn (UKB), the University of Bonn, the Okinawa Institute of Science and Technology Graduate University (OIST) and the RIKEN Center for Brain Science (CBS) assume that the competition between spines for molecular resources and the spatial distance between simultaneously stimulated spines affect their resulting dynamics. The results of the study have now been published in the journal "Nature Communications".

CRISPR gene scissors, as new tools of molecular biology, have their origin in an ancient bacterial immune system. But once a virus attack has been successfully overcome, the cell has to recover. Researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with researchers from the Institut Pasteur in France, have discovered a timer integrated into the gene scissors that enables the gene scissors to switch themselves off. The results of the study have been published in the renowned journal "Nucleic Acids Research".

A low-dose long-term administration of cannabis can not only reverse aging processes in the brain, but also has an anti-aging effect. Researchers from the University Hospital Bonn (UKB) and the University of Bonn together with a team from Hebrew University (Israel) have now been able to show this in mice. They found the key to this in the protein switch mTOR, whose signal strength has an influence on cognitive performance and metabolic processes in the entire organism. The results are now presented in the journal "ACS Pharmacology & Translation Science".

The University Election Assembly of the University of Bonn has elected five female Vice-Rectors and one male Vice-Rector. This completes the team with which Rector Prof. Dr. Dr. h.c. Michael Hoch will start his third term of office in May 2025. Vice-Rectors are part-time and form the Rectorate together with the Rector and Provost Holger Gottschalk.

Food in hospitals often does not enjoy a good reputation. The proportion of meat on the plate in particular is too high and often does not meet the recommendations of the German Nutrition Society (DGE), which advocates a more plant-based diet in hospitals (in German). Clinics can do a lot to motivate patients to choose a healthier menu, as two new studies by Bonn University Hospital (UKB) and the University of Bonn show. Around 2,000 people took part. The results can now serve as a basis for decision-makers in hospitals to make culinary changes. The results of the study will be published in the current August issue of the “Journal of Environmental Psychology”.

The innermost layer of blood vessels is formed by endothelial cells, which in turn play a role in the development of diseases of the cardiovascular system. Human endothelial cells are therefore required for the "in vitro" investigation of the causes of these diseases. Researchers at the University Hospital Bonn (UKB) and the University of Bonn have now established a highly efficient, cost-effective and reproducible way to generate functional endothelial cells from human induced pluripotent stem cells (hiPSCs) for tests in cell culture dishes. The results of the study have now been published in the journal " Cardiovascular Research".

Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal "Human Genetics and Genomics Advances".

The majority of rare diseases have a genetic cause. The underlying genetic alteration can be found more and more easily, for example by means of exome sequencing (ES), leading to a molecular genetic diagnosis. ES is an examination of all sections of our genetic material (DNA) that code for proteins. As part of a Germany-wide multicenter study, ES data was collected from 1,577 patients and systematically evaluated. This made it possible to diagnose a total of 499 patients, with 34 patients showing new, previously unknown genetic diseases. The study thus makes a significant contribution to the initial description of new diseases. In addition, software based on the use of artificial intelligence (AI) was used for the first time on a broad scale to support clinical diagnosis. The "GestaltMatcher" AI system can assist in the assessment of facial features with regard to the classification of congenital genetic syndromes. The results of the study, in which 16 universities and university hospitals were involved, including the University of Bonn, have now been published in the renowned journal "Nature Genetics".